Dialysis is a familiar term to anyone from the Kidney Community, right? It is one of the treatment options for Kidney Failure after all.
BUT DO YOU REALLY UNDERSTAND WHAT EXACTLY IS DIALYSIS ALL ABOUT?
Scroll down or click on the topic-link from the contents list below to learn about all that you must-know about Dialysis, its significance, types, complications, its impact on various facets of our daily life and relevant links to details where necessary.
“Dialysis” (pronounced as “dai-a-li-sis”) basically refers to a process in Chemistry where different particles dissolved in a liquid can be separated based on their ability to pass through tiny pores in a film/membrane.
The word is derived from combining two Greek words “Dia” meaning “apart” and “Luein” meaning “to set free”.
This basic chemical procedure finds its application in clinical medicine in the form of a complex machine called a “Dialyzer”.
This as an indispensable tool used to treat patients who are sick because of an excess accumulation of unwanted wastes or toxins in their bloodstream.
Dialysis helps to artificially remove the excess load of unwanted wastes or toxins in a patient’s bloodstream when their body is unable to do so by itself.
Normally, this task happens to be among the many functions carried out by our Kidneys (via urine) and our Intestines (via faeces).
Any medical condition that affects this waste-clearing mechanism either directly or indirectly results in the levels of unwanted blood wastes to go haywire!
Initially, the medical team will try to treat this with medication. These are usually a combination of medicines taken by mouth, injections & infusions directly into the bloodstream.
If patients do not respond to these medicines and continue to get more sick, patients are put on Dialysis as the last resort.
Such medical conditions include but are not limited to:
1. Kidney failure following Chronic Kidney Disease (Stage 5 CKD or ESRD after eGFR falls below 10%)
2. Acute Kidney Injury complicated with high blood Urea, high blood Potassium, high blood acidity or fluid overload not responding to medication
3. Heart diseases that may cause:
- High blood potassium levels that do not respond to other medicines.
- Excess fluid retention not responding to medication.
- High blood acidity not responding to medicines
4. In some cases of Liver failure.
5. In Stroke patients who are in Coma and are on strong doses of medicines that have harmful side-effects on kidney function.
6. Blood poisoning with kidney-harming drugs/chemicals
Both Dialysis & Kidney Transplant are considered what we technically term Renal Replacement Therapy (RRT). Simply put, these therapies “assist with or take over” the compromised function of unwell kidneys for an overall better blood-component balancing capacity.
When your kidneys fail, dialysis helps restore balance in your blood components by:
1️⃣ Removing metabolic wastes, excess salts and extra water to prevent them from building up in the body
2️⃣ Keeping a safe level of certain minerals / chemicals in your blood, such as potassium, sodium and bicarbonate
3️⃣ Helping to control your blood pressure
However, please understand, Dialysis only helps cover for a fraction of all functions normally performed by kidneys in good health.
Hence, talking in the strictest sense, Dialysis is more of an Assistive Therapy rather than a true Replacement Therapy. As of today, Kidney Transplants are the only viable Renal Replacement Therapy and hence, the best treatment for Kidney failure from CKD.
Broadly, there are two types of Dialysis:
Haemodialysis (pronounced as “hee-mow-dia-lisis”)
Peritoneal Dialysis (pronounced as “peri-tow-nial”)
Hemo = Blood ; Dialysis = Separating out excess wastes
Here, the patient’s blood is directly sent to a dialysis machine for the cleansing procedure.
In hemodialysis, the dialyzer is used to remove waste and excess minerals and fluid from your blood.
Dialysis machines in a hospital appear as a “tall, boxy contraption” with a monitor displaying some “numbers” and attached to numerous tubes. Some of these tubes “dock the patient” to the machine.
Let’s take you through “what’s inside the box” to help you appreciate how Dialysis works.
The following components are necessary for Hemo-Dialyzers to work:
1. TWO “PORTS OF ACCESS” (TUBES) TO THE PATIENT’S BLOODSTREAM:
- One to draw waste loaded blood / fluid and send it to the dialyzer.
- The other, to return cleansed blood/fluid back from the Dialyzer
To insert these ports, the doctor needs to make an entrance into your blood vessels.
Such an Access or Entrance could be a:
👉 SURGICALLY CREATED ACCESS
This is done by a minor surgery to join a suitable artery and a vein in your arm, wrist or leg:
If these blood vessels are joined directly to make a bigger, wider blood vessel, it is called a Fistula.
Alternatively, if your blood vessels are not found suitable for Fistula creation, doctors can use a separate soft plastic tube to join the artery and the vein under your skin. This is called a Graft.
Such a surgical access “designates” a spot for inserting the two ports for multiple dialysis sessions. It virtually eliminates the struggle to map-out appropriate zones and poke two separate needles each time you go for a session.
👉 NECKLINE / CENTRAL LINE / CENTRAL VENOUS CATHETER
Some patients may need Dialysis only for a short time before a planned kidney transplant. In such cases, instead of creating a Fistula or a Graft, your doctor can insert a narrow plastic tube or a Catheter directly into a large vein in your neck under local anaesthesia.
2. A “DIALYZER TANK”
Such a “tank” provides space for the patient’s waste loaded blood to collect outside the body for necessary correction.
3. A SOLUTION CALLED THE “FRESH DIALYSATE”.
Your Dialysis nurse adjusts this Fresh Dialysate to contain minerals and blood proteins in quantities appropriate for restoring normal mineral, protein & fluid balance in the patient’s blood upon “contact”.
4. A “BIO-COMPATIBLE” MEMBRANE / FILM WITH TINY PORES WITHIN THE TANK
- This membrane separates waste-loaded blood from the fresh dialysate and acts as the filter.
- It allows for “controlled exchange” of minerals & plasma protein between the patient’s blood & the Dialysate until “desired correction”.
Think of this membrane as an Immigration Officer at Passport control, you get the idea.
- Your Dialysis team can control this procedure by pre-setting the timer & expected blood correction to be achieved via Dialysis in the “monitor” on the machine.
From the outside, Haemodialysis looks simple. You send your blood to the machine for “servicing” and get the finished product back. But the procedure is far from lucid.
Let’s unravel the details of the valiant journey that your blood undertakes from your body to the Dialyzer and back, to help you appreciate all that goes into assisting your unwell kidneys via Haemodialysis.
🔔 FROM THE PATIENT’S BODY TO THE DIALYZER TANK
- One port (needle accessing the bloodstream) sends the patient’s waste-loaded blood into the Dialyzer Tank. (blue tubing)
- On the way to the tank, there is a thick syringe pumping a chemical called Heparin into the patient’s blood. This is a “blood thinner” that keeps the patient’s blood from clotting during the Dialysis procedure.
- In addition, there are two pressure valves along the way to the Dialyzer Tank:
• The First Pressure Valve helps control the rate at which blood flows out of the patient’s body.
It is crucial that the dialysis team adjusts this pressure to prevent sudden or too rapid outflow of the patient’s blood. Else, the patient stands a risk of losing consciousness & further damage to the kidneys, heart & brain.
• The Second Pressure Valve is located after the “Blood Thinner” Syringe. This valve helps to regulate the pressure at which the patient’s blood, now mixed with Heparin, enters the Dialyzer Tank.
Regulating the Pressure at this valve is essential to allow adequate correction of waste, mineral, protein & fluid levels within the patient’s blood.
Oh Yes, you read that right. Dialysis is all about “Pressure Tactics”!
🔔 WITHIN THE DIALYZER TANK
The fresh dialysate is continuously pumped to the Dialyzer Tank (Yellow tubing in diagram towards tank):
- To “interact & correct” the mineral, fluid & plasma protein content.
- Rid the in the patient’s blood of accumulated metabolic wastes.
The special “bio-compatible porous membrane” within the tank allows for controlled crossing-over of “useful” components such as proteins in the patient’s blood in “adequate” quantities into the fresh dialysate area within the tank.
In return, the waste-load, excess minerals & fluids “stay below”. This fluid now becomes the “Used Dialysate’
Once the “exchange” of the Fresh Dialysate helps restore the balance in the patient’s blood:
- The used Dialysate returns to a separate collection area.
- The “clean” blood is pumped back into the patient’s bloodstream.
🔔 FROM THE DIALYZER BACK TO THE PATIENT’S BODY
1. The cleansed & balanced blood flows back to the body through another Pressure Monitor. This prevents the blood from gushing back to the patient’s bloodstream with unnecessary force which could otherwise potentially injure the vein and scar it.
2. In addition, an Air trap & bubble detector monitors the inflowing blood for large air bubbles. This is necessary to prevent large air bubbles from potentially blocking your natural blood flow within the body. Such bubbles could otherwise cause heart attacks, strokes or even sudden death.
The time needed for your haemodialysis session depends on:
1️⃣ How well your kidneys work
2️⃣ The fluid weight you gain between treatments
3️⃣ The waste content you have in your blood
4️⃣ Your body surface area (how big you are)
5️⃣ The type of dialyzer used
6️⃣ A typical hemodialysis treatment course requires three days of your week and 4 hours per session.
7️⃣ High flux dialysis is a type of hemodialysis that may take less time. You can speak to your doctor to see if this is an appropriate treatment for you.
Peritoneal = Of peritoneum; Peritoneum = A thin porous tissue-sheet covering our intestines with very rich blood supply.
Here, instead of sending the patient’s blood to the dialyzer tank outside the body, the patient’s abdomen acts as the “Dialysis Tank” itself.
The ability of the peritoneum to act as the dialysis membrane within the body itself forms the basis for this variation.
In this type of dialysis, the blood cleansing takes place inside your body, as shown in the Illustration below:
👉 The doctor will surgically place a plastic tube called a catheter into your abdomen (belly) to make a long-term access beforehand. This plastic tube stays in place even when the person is not undergoing dialysis.
👉 During the treatment, your abdominal area (called the peritoneal cavity) slowly fills up with dialysate through the catheter.
👉 Your blood continues to circulate within the blood vessels (arteries and veins) that line your peritoneal cavity as usual. The blood vessel walls and the tissue lining of peritoneum act as a “continuous exchange-filter space”.
👉 The blood within the arteries & veins normally circulates at a higher pressure than the dialysate fluid that is filled in the peritoneal space. This allows for the extra fluid & waste products in the blood to move out into the dialysate.
There are two major kinds of peritoneal dialysis:
1️⃣ Continuous Ambulatory Peritoneal Dialysis (CAPD)
2️⃣ Automated Peritoneal Dialysis (APD).
🔔 Continuous Ambulatory Peritoneal Dialysis (CAPD)
This is the only type of peritoneal dialysis that does not require machines. Patients do this themselves, usually four or five times a day at home and/or at work.
The patient puts a bag of dialysate (about two quarts) into his/her peritoneal cavity through the catheter. The dialysate stays there for about four or five hours before draining it back into the bag and disposing of it. The technical name for this procedure is an Exchange.
Everytime patients do an Exchange, they need a fresh, new bag of Dialysate.
While the dialysate is in their peritoneal cavity, patients can go about their usual activities at work, at school or at home.
🔔 Automated Peritoneal Dialysis (APD)
APD usually is done at home using a special machine called a Cycler (image below).
APD is similar to CAPD except that a number of cycles (exchanges) occur. Each cycle usually lasts 1-1/2 hours and exchanges are done throughout the night while patients sleep.
Despite being a life-saving intervention, we cannot deny the fact that both kinds of Dialysis are ultimately an “external interference” in the usual work-flow of the human body. This is bound to invite some complications related to the procedure, especially in the long run.
Both Haemodialysis & Peritoneal Dialysis efficiently cleanse blood of wastes to help unwell kidneys marred by CKD. This effectively prolongs patient survival as well. However, both these Dialysis types have their share of side effects as discussed below.
1. Port Access (Fistula/Graft/Neckline) Complications:
- Infection of the fistula site with subsequent spread into the bloodstream
- Clotting in and blockage of the operated blood vessels (fistula/graft site)
- Easy bleeding from minor trauma
- Aneurysm refers to excess bulging of fistula & weakening of vessel walls
- Poor Skin integrity at the site over the bulged fistula
2. Haemo-dynamic problems
- Fluctuation in blood pressure
Sudden “correction” of fluid levels in the blood after a Haemodialysis session can frequently manifest as a sudden fall in Blood pressure & extreme tiredness.
- Occasional Chest pain
This is likely due to abrupt changes in body water content during Dialysis that “burdens” the heart. It could also result from disease of blood vessels to the heart that is common in CKD.
- Poor control over decline of blood Albumin levels
This reduces the “oncotic pressure” & promotes limb swelling due to fluid accumulation
3. Blood mineral imbalance
- Muscle cramps especially in the calves.
This is due to rapid changes in blood Sodium & Potassium levels during Dialysis cycles. It can be avoided by suitably adjusting the Fresh Dialysate within the Dialysis machine.
- Poor control of raised blood phosphate levels from CKD.
This worsens Bone pain & increases chance of getting Kidney Stones.
- Anaemia due to iron deficiency from loss of extra blood during each Haemodialysis session. This worsens the already anaemic state caused due to kidney failure.
4. Neurologic complications
Headaches are extremely common in all Haemodialysis patients due to abrupt & large changes in body fluid and mineral levels after every session.
- Dialysis associated Dementia (forgetfulness)
This is attributed to Aluminium toxicity in blood & low blood pressure in HD patients
This is treatable by making adjustments to Aluminium levels in the Dialysate fluid and with medication to “bind to” & reduce blood Aluminium levels.
- Wernicke’s Encephalopathy
This complication involves inflammation of brain tissue due to Vitamin B1 deficiency.
This condition manifests as difficulty in eye movements, imbalance in body movements & confusion.
It is reversible by treating with Vitamin B1 injections/infusion.
- Dialysis disequilibrium syndrome
This complication is rare and is seen in patients who are irregular with their Haemodialysis treatment msessions.
It is a set of neurologic symptoms including but not limited to headache, nausea, blurred vision. It occurs due to excess fluid accumulation in the brain.
Stroke or “brain attack” presents as paralysis due to sudden, poor blood supply to a part of the brain.
In hemodialysis patients, this could occur because of increased chances of abnormal blood clotting and poor heart pumping as side effects of the dialysis procedure over time.
Peritoneal Dialysis invites fewer complications in the short term unlike Haemodialysis. This is because it is gentler and does not involve changing blood vessel dynamics through a Fistula or Graft creation as in Haemodialysis.
- Catheter site infection
Poor hygiene of the site on your tummy where the catheter is inserted, could cause infections locally.
This refers to infection of the peritoneum (biological tissue bag within the abdomen) that acts as the “filter space” in Peritoneal Dialysis
The Catheter for Peritoneal Dialysis is basically a “foreign body” that stays put even when the patient is not getting dialysis. So, it can act as a “portal of entry” for infection causing germs into the otherwise sterile abdominal cavity as well.
Peritonitis is a dangerous & extremely painful complication. The good news is,it is entirely preventable by maintaining strict hygiene at all times, especially at the catheter site.
Although initially, Peritoneal Dialysis comes with a lot less complications than Haemodialysis, in the long run (think in terms of a decade), PD patients end up with many complications that are otherwise seen in HD patients initially.
- Weight Gain
- Heart enlargement and poor pumping
- Sustained increase in blood Phosphate levels that can worsen bone pain & cause kidney stones
- Poor control over decline of blood Albumin levels
This is a frequent question in all kidney patient circles that we at Team ATK have come across.
Selecting which Dialysis modality to start a kidney patient on, is a crucial step in the treatment of kidney failure. It is your medical team that must take the final call on which Dialysis Type suits you best.
But as we, at Team ATK always say, knowing precisely as to what your medical condition is about, & how your medical team takes clinical decisions for you significantly helps you to adhere to your treatments & ensure favourable clinical outcomes for you. Add to that, the kind of control that you gain over your life, and proactively learning about your health turns simply empowering!
So, let’s learn about this topic.
There are various factors pertaining to both patients & physicians play a role in deciding which Dialysis type suits you.
Let us compare how the two types of Dialysis work on individual parameters that determine the overall clinical outcome in patients with kidney failure.
|Typical Patient Profile||Eligible patients are not acutely sick, are usually young (<40 years) and non-diabetic without heart disease.||Older patients >65 years with Diabetes and those with Congestive Heart Failure (CHF) fare poorly on PD. They need to be initiated on HD (2004 study)|
| Survival Advantage |
~ Does one Dialysis type prolong your life more than the other?
|1. Survival advantage reported in PD patients by at least 2 years as compared to HD, especially in non-diabetics and young diabetics below 65 years|
2. A prospective study in 2004 showed Older patients with Diabetes or CHF do not benefit from PD
3. A "retrospective" study in patients on dialysis since 2003 showed that the “intention to treat mortality” is 8% lower in PD than for matched HD patients.
In easier words, less number of patients are likely to progress to life-threatening stages with PD as compared to HD for a given time frame.
|Haemodialysis certainly prolongs lives of patients with kidney failure by at least 5 years than living without Dialysis or Transplant.
However, NO survival advantage has been reported for HD patients over PD.
This means, any kidney patient is unlikely to survive longer with HD than if they were on PD.
~ Calculated by a ratio called Kt/V
~ This ratio compares the amount of water that passes through the dialyzer & is cleared of Urea to the amount of water in the patient’s body.
~ For an adequate cleansing of the blood of Urea, the desired minimum value for Kt/V is 1.2
|Current recommendations for weekly PD gives a KT/V of 1.7||Single pool HD gives an "inadequate" KT/V of 0.95.|
|ESA dependence |
~ ESA stands for Erythropoietin Stimulating Agents
~ These are injections of the hormone necessary to form red blood cells (The hormone is normally produced in kidneys. Its levels decline with kidney failure. This needs treatment with ESAs in due course)
|Less ESA dependence in PD than HD. (Perhaps indicates better preservation of some kidney functions in the short term as compared to HD)||Patients on HD tend to be more ESA dependent (Poor RBC numbers)|
|Serum (blood) Phosphate control |
~ This pertains to how well bone disease in kidney failure and kidney stone formation can be prevented
|Better serum Phosphate control in PD initially although time averaged values come out higher than HD.||Poor initial outcome of HD on Serum Phosphate values (poor control),|
|Dialysis associated Heart Disease||1. In PD sessions, body fluid volume changes are gradual. Hence an average PD session is more soothing on heart as compared to an HD session.|
However, heart enlargement (LVH) instances match up with HD in the longer run (in a few years time)
|1. Removes extra fluid from the body aggressively over a shorter time span, hence better for patients who already have Congestive Heart Failure.
In such patients, fluid overload in the body spells further difficulty with heart pumping in an already failing heart.
2. Conversely, in patients who do not have prior heart disease, a separate set of heart side-effects is possible.
The aggressive fluid "relief" that otherwise helps heart failure patients can stun & strain healthy hearts. This is due to abrupt fluid volume adjustments with each session.
Hence, dialysis-associated heart enlargement can set in earlier in kidney patients with relatively healthy hearts on HD than in PD.
|Maintenance of Serum Albumin (plasma protein) levels||Poor maintenance of Serum Albumin levels in patients on PD than HD.|
However, the fact that there is no strict protocol in place to advise protein supplement powders in PD patients adds to this scenario.
|Better maintenance of serum Albumin levels (marginally higher than PD)
probably due to added help from protein supplementation.
|Session Efficiency||Less efficient method (PD 168 hrs/week) than HD (12 hrs/week) but continuous (in CAPD), not abrupt, hence easier on the body.||More efficient in clearing uremic toxins than PD but abrupt and intermittent (12 hrs /week in thrice weekly sessions), hence harsher on the body.|
|Side effects that can impact Patient Preference||1. Weight gain and potential infection of the peritoneum (if catheter hygiene not maintained) are possible complications. |
2. Carrying a catheter attached to the abdomen may also not be acceptable to some patients for social reasons.
|Blood infections, infections of the “port access”, blood pressure fluctuations & extreme fatigue after each session are common complications of HD. These can skew patients in favour of PD.|
|Quality of life||Better comfort, can be done at home upon suitable training. |
Such "freedom of choice" with regards to the time & place of Dialysis can promote a selection bias in younger patients in favour of PD (especially those who have employment commitments)
|Patients have to depend on external dialysis facilities. Hence, less preferable by younger & employed patients who are eligible for both HD & PD.|
|Insurance Reimbursement for Healthcare Providers|
(for US Healthcare)
|Earlier, HD prescriptions attracted higher reimbursements than PD. Conversely, current norms are gradually turning in favour of home-based Peritoneal Dialysis.||Traditionally, insurance reimbursements have favoured In-Centre Haemodialysis. However, an opinion shift is underway, gradually turning towards Home based PD unless otherwise necessary.|
With amply ambivalent outcomes, simply choosing one method of Dialysis when required, would be, as nephrologist Dr. Roger Rodby rightly says in this AJKD blog post, akin to “Dorothy asking for directions from the Scarecrow”.
Choosing an integrated care approach with a “healthy start” and a dynamic course is the most sensible approach. This means PD can make for a better option for the initial renal replacement therapy (unless the patient is clearly expected to fare better on HD). This can be followed by timely transfer to HD once PD starts showing complications that overtake those of HD in the longer run. Going by the present research evidence, such an integrated approach may improve the long-term survival of ESRD patients.
Does dialysis cure kidney failure due to chronic kidney disease? No. Dialysis assists your unwell kidneys with clearing out wastes from your blood. And this is only a fraction of all the work that healthy kidneys do. Dialysis is simply a treatment. It does not cure your kidney disease.
In a nutshell, Dialysis is a kidney-supportive therapy that needs to be continued your whole life or up until you receive a kidney transplant.
When on Dialysis, our bodies undergo immense changes over a relatively short time frame. To better cope up with these changes, we require a special set of nutrients, at the same time keeping in mind the dietary restrictions that apply with Chronic Kidney Disease.
Your doctor will send you to a Renal Dietitian to get your Special Dialysis diet plan. This also includes guidelines on your daily liquid intake.
Another point to note is that your diet will depend on the type of Dialysis you are on and its resulting changes to blood components.
YES! Dialysis only helps cleanse the excess waste load of your blood and retain the necessary minerals in appropriate amounts. However, this is only a fraction of all the functions that kidneys perform functions that kidneys perform.
To compensate for all the other functions of a healthy kidney which remain compromised with kidney failure, it is imperative that you continue on all your Prescription medicines for kidney disease.
DO NOT START ANY NEW MEDICINE / HERBAL OR NATUROPATHIC THERAPY without consulting your medical team to avoid adverse drug reactions or add unnecessary burden to already unwell kidneys.
Dialysis is expensive. The overall cost per patient varies across countries based on drug/medical device/health service pricing policies set up by the respective Health Ministry.
However, in most countries, Kidney failure is recognized as a focus area of prime importance. Hence, the Government bears the major chunk of the treatment cost in every Government-operated health facility. The patient party pays for the remaining fraction either out of their own pocket or via health insurance plans.
For instance, the US federal government pays 80 percent of all dialysis costs for most patients. Private health insurance or state Medicaid programs also help with the costs.
Dialysis per se does not hinder you from continuing with your employment. If you are responding well to dialysis treatments, you can go back to work, especially after having gotten used to your dialysis routine. However, please note the following:
1. If your job involves physical labor (heavy lifting, digging, etc. ), you may need to get a different job. Avoid lifting heavy weight at all times.
2. Patients on Haemodialysis may either need to talk to the Dialysis center to adjust the timing of their thrice-weekly sessions outside of their work hours. Alternatively, if suitable, you may need talk to your employer for flexibility in work hours. In short, do not miss your Dialysis Sessions at any cost. Talk to your medical team if Home Dialysis could be a viable option for you.
3. Patients on Peritoneal Dialysis or with a Neckline must maintain proper Catheter hygiene. This is to prevent any potential infection from entering the bloodstream and causing serious complications.
Traveling while on Haemodialysis or Peritoneal Dialysis is NOT a risk till you meet the following criteria:
1. Your medical reports are stable
2. You do not lift heavy weight (luggage) or go for intense outdoor activities.
3. You do not miss your routine Dialysis sessions, else you stand the possibility of showing complications. Talk to your regular Dialysis Center to see if they could make arrangements to accommodate you at a reliable local Dialysis unit at the place where you are headed to.
As explained in this section, Dialysis is a method to help clear the blood of excess wastes and fluid which can be used in a number of medical conditions as listed here, and NOT JUST kidney failure due to Chronic Kidney Disease.
In all those cases that require Dialysis, except for Kidney Failure due to CKD, a kidney transplant is unlikely to be necessary.
In addition, if you are a CKD patient on Dialysis and are too unstable to undergo long surgeries like a Transplantation, you will be advised to stay on life-long Dialysis.
Yes. If you are diagnosed with chronic kidney disease before your kidney function or your GFR number falls below 10 ml/min, and you have potential, matched kidney donors who are willing to help, you can opt for what we call a Pre-emptive transplant.
In the clinic, the word “Pre-emptive” refers to any medical intervention taken in good time before an expected health complication sets-in. Because all patients with advanced Chronic Kidney Disease with GFR numbers less than 15 progress to a “point-of-no-return“, they are assessed if they are stable enough to undergo a transplant surgery even before starting them on any assistive therapy like Dialysis. This usually coincides the point when your Serum Creatinine values in your bloodwork cross 6 mg/dL.
Such kidney transplants that are conducted in patients with kidney failure, upon anticipating the “point-of-no-return” without starting the patient on Dialysis is termed Pre-emptive Kidney Transplant.
It is a good option especially with young patients under 30 years so as to avoid complications from Dialysis restricting the quality of life.
Obviously, pre-emptive transplant is only possible when you have a willing, matched & healthy kidney donor available at your side in good time.
- Who needs Dialysis? ~ Medscape
- Dialysis ~ BMJ
- Complications of Dialysis ~ Medscape
- Headache in Haemodialysis patients
- Dialysis associated Dementia
- Wernicke’s Encephalopathy in Haemodialysis patients
- Disequilibrium Syndrome associated with Haemodialysis
- Haemodialysis & Stroke
- Which road do we take? PD or HD ~ by Dr. Roger Rodby (AJKD Blog)
- Choosing the Dialysis type
- Understanding KtV ~ Yale Coursepress