COVID19 Vaccines vs Evusheld ® vs Mask: What works the best in Immunocompromised?

COVID19 prevention has been a tough nut to crack especially in the Immunocompromised. On one hand, the COVID19 vaccines fell short in patients with moderate to severe weakening of immunity. This included kidney patients with advanced pre-dialysis state, those on dialysis and post-transplant. On the other, in certain kidney patient cohorts who did develop traceable immune response to the vaccines ended up with a flaring of pre-existing underlying autoimmune kidney diseases like IgA Nephropathy.

Then we have Evusheld ® – drug maker AstraZeneca’s new long acting monoclonal antibody combo shot. This antibody drug (generic name: AZD7442) was granted an Emergency Use Authorization by the USFDA on December 8th, 2021. With its “ready-made immune protection”, this long acting antibody (LAAB) drug shows promise in preventing symptomatic COVID19 in immunocompromised patients (just like vaccines do in immunocompetent). However, only time will tell how well it performs on-field. Read more here.

But then, amidst this steady inflow of pharmacological strategies to ward-off COVID19, if something has managed to survive it’s the utility of the humble face mask. Of-course, other COVID safe practices like following strict hygiene protocols and avoiding crowds go hand-in-hand.

So what works the best?

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Blood in Urine: Can it be resolved?

Haematuria (Red blood cells in urine) is not a disease in itself. It is a “sign” that points to an abnormality within your body.

The treatment approach towards haematuria would require a confirmed diagnosis of the underlying cause and adopting relevant medical and/or corrective surgical approaches. Whether it can be resolved completely or not would entirely depend on its root cause.

Link blood in urine

Presenting here, the general pointers that guide your treatment plan for patients with Haematuria.

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Blood in Urine: How to pinpoint the site of bleeding?

Haematuria (blood in urine) is a common reason for “Red Urine” in patients with Kidney and Urinary tract diseases.

If you consult your doctor for reddish discoloration of your urine, your doctor will first:

Clinical workup hematuria

Based on the clinical examination, you will be advised necessary laboratory-based tests to confirm the presence of blood in your urine.

These tests would also allow your doctor to get an approximate idea of where the blood could have been coming from, into your urine.

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Blood in Urine: The Bare Basics of Haematuria

Haematuria

WHAT IS HAEMATURIA?

Haematuria is the technical term for the presence of red blood cells (RBCs) in urine. This could range from minute quantities such that it is invisible to the naked eye (occult or hidden bleeding), to frank hematuria such that the urine assumes a reddish tinge to a cola-coloured appearance.

Red blood cells abundantly present in our bloodstream happen to carry a pigment called “Haemoglobin” within them. This is what gives our blood, a red colour and lends that reddish tinge to most urine samples that have blood in it.

Please note: For Haematuria, the urine sample must contain whole red blood cells and not just the red pigment of blood.

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