#immunosuppression Archives - All Things Kidney ~ Official

COVID19 Vaccines vs Evusheld ® vs Mask: What works the best in Immunocompromised?

December 17, 2021May 11, 2022Leave a comment

COVID19 prevention has been a tough nut to crack especially in the Immunocompromised. On one hand, the COVID19 vaccines fell short in patients with moderate to severe weakening of immunity. This included kidney patients with advanced pre-dialysis state, those on dialysis and post-transplant. On the other, in certain kidney patient cohorts who did develop traceable immune response to the vaccines ended up with a flaring of pre-existing underlying autoimmune kidney diseases like IgA Nephropathy.

Then we have Evusheld ® – drug maker AstraZeneca’s new long acting monoclonal antibody combo shot. This antibody drug (generic name: AZD7442) was granted an Emergency Use Authorization by the USFDA on December 8th, 2021. With its “ready-made immune protection”, this long acting antibody (LAAB) drug shows promise in preventing symptomatic COVID19 in immunocompromised patients (just like vaccines do in immunocompetent). However, only time will tell how well it performs on-field. Read more here.

But then, amidst this steady inflow of pharmacological strategies to ward-off COVID19, if something has managed to survive it’s the utility of the humble face mask. Of-course, other COVID safe practices like following strict hygiene protocols and avoiding crowds go hand-in-hand.

So what works the best?

Continue reading “COVID19 Vaccines vs Evusheld ® vs Mask: What works the best in Immunocompromised?” →

Evusheld ® : “Readymade” Immune Protection against COVID-19 in Immunocompromised

December 15, 2021December 19, 2021Leave a comment

When vaccines fall short in offering relevant immune protection in the Immunocompromised, what really works? When such suboptimal immune protection wanes a lot faster in comparison to that immunocompetent individuals, is there a better option?

“Ready-made”, sustainable Immune Protection perhaps?

Well that’s exactly what Evusheld ® – drugmaker AstraZeneca’s “New Kid on the Block” in the long-acting monoclonal antibody drug combo can potentially offer.

Continue reading “Evusheld ® : “Readymade” Immune Protection against COVID-19 in Immunocompromised” →

Poor response to COVID Vaccine in Kidney Patients: Decode the Science-Understand your Options

November 10, 2021December 30, 2021Leave a comment

COVID19 vaccine inoculations are the best possible protection for most health profiles that science offers against this pandemic menace. However, as we know, COVID vaccines in their initially recommended dose schedules proved less effective in immunocompromised individuals. This was irrespective of whether poor immunity resulted from a medical condition or due to immuno-suppressive medication. Patients with advanced Chronic Kidney Disease & Kidney Transplant recipients are a prominent subgroup in this population subset of the “Vaccine Helpless”.

◾ So how did poor immunity in kidney patients impact vaccine effectiveness?

◾ Will repeated immune challenge with extra doses as part of primary vaccine series truly help all kidney patients? How tenable is it?

◾ Any better alternatives to garner adequate immune protection for our cohort without going overboard with the “immune challenge” and/or inviting side-effects of major concern?

Read on to decode the relevant science and understand your options for adequate immune protection against COVID-19.

(DISCLAIMER: The article is purely a medically feasible insight on current evidence from peer-reviewed scientific literature on COVID-19 vaccine efficiency, its shortcomings & potential relevant alternative pharmacological solutions w.r.t. patients with chronic kidney disease. The intention is to place the facts as they are with due respect to Science. It is not intended to promote any vaccine hesitancy or support anti-vaxxer views. It does not represent any political positioning either.)

Continue reading “Poor response to COVID Vaccine in Kidney Patients: Decode the Science-Understand your Options” →

Kidney Transplant: Hospital Recovery after the Surgery

August 27, 2021September 3, 2021Leave a comment

Imagine this. You’re yet to open your eyes, but you’re conscious. You can hear hushed voices around you, sense a strong ambient smell, get a feeling of being “lifted & wheeled somewhere”. At a point, you feel a sudden pain on one side of your lower abdomen. It’s only a matter of time that you open your eyes nice & wide and if health & luck are on your side, you recognize most of those masked faces, where you are and what you just underwent. Wondering what’s this all about? Well, that’s my own experience of waking-up after my Kidney Transplant Surgery.

Of course things may differ individually, depending on how the new kidney works in a recipient and his/her general health. Despite variable experiences, once you do wake up, you officially enter the Transplant Survivor Club. Congratulations!

So how does the rest of your hospital stay look like?

That is what we aim to walk you through, with this article.

Continue reading “Kidney Transplant: Hospital Recovery after the Surgery” →

Kidney Transplant: Before the surgery – II

December 13, 2020May 21, 2021Leave a comment

Transplant

Hello kidney warriors & knowledge seekers! Today, we continue from our previous article on all steps that kidney patients & kidney donors need to follow before getting admitted to the hospital for a Transplant surgery.

The article today explains the basic workflow involved for every kidney patient scheduled for a transplant & their donor starting from hospital admission until they finally get to go under the knife.

Continue reading “Kidney Transplant: Before the surgery – II” →