The COVID19 pandemic has generally seen children co-operating with following necessary precautions. However, rampant misinformation circulating online has also had its toll on impressionable minds in the form of harmful anti-mask & anti-immunization (without medical reasons) attitudes. Moreover, stringent posturing, a chastising rhetoric and occasional confused messaging by some frustrated authorities w.r.t. COVID19 policies are only proving counter-productive.
COVID19 prevention has been a tough nut to crack especially in the Immunocompromised. On one hand, the COVID19 vaccines fell short in patients with moderate to severe weakening of immunity. This included kidney patients with advanced pre-dialysis state, those on dialysis and post-transplant. On the other, in certain kidney patient cohorts who did develop traceable immune response to the vaccines ended up with a flaring of pre-existing underlying autoimmune kidney diseases like IgA Nephropathy.
Then we have Evusheld ® – drug maker AstraZeneca’s new long acting monoclonal antibody combo shot. This antibody drug (generic name: AZD7442) was granted an Emergency Use Authorization by the USFDA on December 8th, 2021. With its “ready-made immune protection”, this long acting antibody (LAAB) drug shows promise in preventing symptomatic COVID19 in immunocompromised patients (just like vaccines do in immunocompetent). However, only time will tell how well it performs on-field. Read more here.
But then, amidst this steady inflow of pharmacological strategies to ward-off COVID19, if something has managed to survive it’s the utility of the humble face mask. Of-course, other COVID safe practices like following strict hygiene protocols and avoiding crowds go hand-in-hand.
So what works the best?
COVID19 vaccine inoculations are the best possible protection for most health profiles that science offers against this pandemic menace. However, as we know, COVID vaccines in their initially recommended dose schedules proved less effective in immunocompromised individuals. This was irrespective of whether poor immunity resulted from a medical condition or due to immuno-suppressive medication. Patients with advanced Chronic Kidney Disease & Kidney Transplant recipients are a prominent subgroup in this population subset of the “Vaccine Helpless”.
◾ So how did poor immunity in kidney patients impact vaccine effectiveness?
◾ Will repeated immune challenge with extra doses as part of primary vaccine series truly help all kidney patients? How tenable is it?
◾ Any better alternatives to garner adequate immune protection for our cohort without going overboard with the “immune challenge” and/or inviting side-effects of major concern?
Read on to decode the relevant science and understand your options for adequate immune protection against COVID-19.
(DISCLAIMER: The article is purely a medically feasible insight on current evidence from peer-reviewed scientific literature on COVID-19 vaccine efficiency, its shortcomings & potential relevant alternative pharmacological solutions w.r.t. patients with chronic kidney disease. The intention is to place the facts as they are with due respect to Science. It is not intended to promote any vaccine hesitancy or support anti-vaxxer views. It does not represent any political positioning either.)
Muscle wasting & pain is a common complication reported in most patients with Chronic Kidney Disease, worldwide. Speaking from personal experience, this is also one of those “visibly apparent” physical changes in the course of CKD, which can have a negative impact on our already complicated quality of life.
So, can you prevent this from happening? Well, that’s the million-dollar (research) question, isn’t it?
In our previous article in this category, we covered the whole bunch of causes that conspire together in CKD to make your muscles gradually “lose themselves” over time. Fortunately, medical research has offered us effective solutions to keep muscle wasting in CKD at bay for as long as possible. In addition, some approaches can also partially restore muscle bulk and strength after muscle wasting has already started.
Let’s explore these treatments then, shall we?
Muscle Pain & wasting (shrivelling) is a constant, debilitating & rather frustrating accompaniment during your CKD journey, in the advanced stages. It is only but one of the many myriad “complaints” arising from across multiple organs — something that’s a part & parcel of Chronic Kidney Disease (CKD).
Adding to this list, today we seek to cover the significance of skeletal muscles in kidney disease and explain why muscles begin to “lose themselves” when we enter the great abyss of Chronic Kidney Disease!
But first things first. Continue reading “Muscle Pain & Wasting in CKD”
Bone Pain Muscle Pain
Pain as a sensation, wherever it might arise from, is solely felt because nerves present in that region relay it to our brain and back. This is a “protective reflex”, Continue reading “Bone Pain vs Muscle Pain in CKD”
Bone pain is an inevitable consequence of advanced Chronic Kidney Disease. Our previous article explained why this is the case. We elucidated on the “crosstalk” that exists between kidneys and bones in normal health, and how their “relationship turns painful” when Chronic Kidney Disease hits!
This article serves to cover the treatment principles that help make that debilitating pain go away, literally by acting as “relationship counsellors” for the Kidney & Bones.
Let’s get started then, shall we? Continue reading “Bone Pain in CKD: Treatment”
Most members of Club CKD are well-acquainted with that debilitating knee or lower back pain which intensifies as kidney failure approaches.
Your medical team gets your bloodwork done & may be able to relate this pain to desperately low levels of Vitamin D!
(provided you don’t already have a separate bone or nerve condition)
But we’re talking about Chronic Kidney Disease, right? What does Vitamin D have anything to do with it? And how does that cause you bone pain? Let us try & dissect this topic, shall we? Continue reading “Bone Pain in Chronic Kidney Disease”